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As noted by Kraus et al., Nature Medicine , NNMT inhibition in white adipose tissue significantly increased energy expenditure and reduced fat mass in animal models without changes to diet or activity

Although you may eat plenty of B-12-enriched food, your body may not absorb it or use it efficiently due to aging, alcohol intake, and pollutants from the environment, all of which can take a toll on your body and digestion

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Discussion Effective interventional treatments are critically needed to address ever-increasing rates of global obesity and obesity-linked comorbidities